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Drug-Resistant Staph: What You Need to Know
| A virulent strain of bacteria that resists many antibiotics appears to be killing more people annually than AIDS, emphysema or homicide, taking an estimated 19,000 lives in 2005, according to a study published last week in the Journal of the American Medical Association. |
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'...taking an estimated 19,000 lives in 2005...can prey on otherwise healthy people.'
Tuesday, October 23, 2007
Drug-Resistant Staph: What You Need to Know

Custodian Don Watkins disinfects a high school locker room in Sarasota, Fla., last week after three area students were diagnosed with staph infections. (Chip Litherland/The New York Times)
For years health authorities have warned of the growing threat posed by drug-resistant bacteria, but most of us have been half-listening. Not anymore.
A virulent strain of bacteria that resists many antibiotics appears to be killing more people annually than AIDS, emphysema or homicide, taking an estimated 19,000 lives in 2005, according to a study published last week in the Journal of the American Medical Association. The recent death of a 17-year-old high school football payer in Virginia is a tragic reminder that methicillin-resistant Staphylococcus aureus, or MRSA, can prey on otherwise healthy people.
The best defense against the potentially deadly infection is common sense and cleanliness. “We need to reinvent hygiene for the 21st century,’’ said Dr. Charles Gerba, professor of environmental microbiology at the University of Arizona at Tucson. “You go to a grocery store, and hundreds of thousands of people have touched those surfaces every day. Microorganisms are evolving very rapidly.’’
Here are answers to common questions about community-acquired staph infections, or CA-MRSA.
What does CA-MRSA look like?
CA-MRSA is primarily a skin infection. It often resembles a pimple, boil or spider bite, but it quickly worsens into an abscess or puss-filled blister or sore. Patients who have sores that won’t heal or are filled with pus should see a doctor and ask to be tested for staph infection. They should not squeeze the sore or try to drain it — that can spread the infection to other parts of the skin or deeper into the body.
Who is at risk?
The vast majority of MRSA cases happen in hospital settings, but 10 percent to 15 percent occur in the community at large among otherwise healthy people. Infections often occur among people who are prone to cuts and scrapes, such as children and athletes. MRSA typically spreads by skin-to-skin contact, crowded conditions and the sharing of contaminated personal items. Others who should be watchful: people who have regular contact with health care workers, those who have recently taken such antibiotics as fluoroquinolones or cephalosporin, homosexual men, military recruits and prisoners. Clusters of infections have appeared in certain ethnic groups, including Pacific Islanders, Alaskan Natives and Native Americans.
What can I do to lower my risk of contracting MRSA?
Bathing regularly and washing hands before meals is just a start. Wash your hands often or use an antibacterial sanitizer after you’ve been in public places or have touched handrails and other highly trafficked surfaces. Make sure cuts and scrapes are bandaged until they heal. Wash towels and sheets regularly, preferably in hot water, and leave clothes in the dryer until they are completely dry. “Staph is a pretty hearty organism,’’ said Dr. Gerba.
Remind kids and teenagers that personal items shouldn’t be shared with their friends, he added. This includes brushes, combs, razors, towels, makeup and cell phones. A teenager in Dr. Gerba’s own family once contracted MRSA, he said, and he eventually traced the bacteria to her cell phone. She had shared it with a friend whose mother worked in a nursing home. Dr. Gerba went on to discover MRSA on the friend’s cell phone and makeup compact and on a countertop in her home.
Where does MRSA lurk?
The bacteria may be found on the skin and in the noses of nearly 30 percent of the population without causing harm. Experts believe it survives on surfaces in 2 percent to 3 percent of homes, cars and public places.
But the bacteria are evolving, and the statistics may already underestimate the prevalence of MRSA. Be especially vigilant in health clubs and gyms — staph grows rapidly in warm, moist environments. The risks of infection and necessary precautions should be explained to student athletes, particularly those in contact sports who often suffer cuts and spend time in locker rooms. When working out at the gym, make sure you wipe down equipment before you use it. Many people clean just the sweaty benches, but Dr. Gerba notes that MRSA also has been found on the grips of workout machines. And if you have a scrape or sore, keep it clean and bandaged until it heals. Minor cuts and scrapes are the way MRSA takes hold.
What is the single best thing I can do to protect myself from MRSA?
Without question, people need to show far more respect for antibiotics. Misuse of antibiotics allows bacteria to evolve and develop resistance to drugs. But parents often pressure pediatricians to prescribe antibiotics even when they don’t help the vast majority of childhood infections. When you do take an antibiotic, finish the dose. Antibiotic resistance is bad for everyone, but your body can also become particularly vulnerable to resistant bacteria if you are careless with the drugs.
How do I find out more?
One of the most useful Web sites is a MRSA primer from Mayoclinic.com. The Centers for Disease Control and Prevention offers a useful Q&A about MRSA in schools. A patient website called MRSA Resources lists a few stories of patients affected by MSRA. Recent Stanford University grad Nick Yee chronicles his struggle with MRSA on his Web site, which includes graphic videos of his wound and treatment. (I couldn’t get through them.) And if you have the stomach for it, a number of people have — inexplicably — posted videos of their MRSA wounds on YouTube.
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Wednesday, October 24, 2007
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AIDS (Acquired Immune Deficiency Syndrome) is the final and most serious stage of HIV disease, which causes severe damage to the immune system.
According to the Centers for Disease Control and Prevention, AIDS begins when a person with HIV infection has a CD4 cell count below 200. CD4 cells are also called "T-cells" or "helper cells"; they are a type of immune cell. AIDS is also defined by numerous opportunistic infections and cancers that occur in the presence of HIV infection.
Times Essentials
By ABIGAIL ZUGER, M.D.
The first thing we want to know about a disease is whether it is going to kill us. For AIDS, we really cannot answer the question well at all.
25 Years of Covering AIDS
Complete Archive
Reference from A.D.A.M.
Acquired immune deficiency syndrome
AIDS is the fifth leading cause of death among persons between ages 25 and 44 in the United States, down from number one in 1995. About 25 million people worldwide have died from this infection since the start of the epidemic, and 40.3 million people are currently living with HIV/AIDS globally
Human immunodeficiency virus (HIV) causes AIDS. The virus attacks the immune system and leaves the body vulnerable to a variety of life-threatening infections and cancers.
Common bacteria, yeast, parasites, and viruses that ordinarily do not cause serious disease in people with healthy immune systems can cause fatal illnesses in people with AIDS.
HIV has been found in saliva, tears, nervous system tissue and spinal fluid, blood, semen (including pre-seminal fluid), vaginal fluid, and breast milk. However, only blood, semen, vaginal secretions, and breast milk generally transmit infection to others.
Transmission of the virus occurs:
- Through sexual contact -- including oral, vaginal, and anal sex
- Through blood -- via blood transfusions (now extremely rare in the U.S) or needle sharing
- From mother to child -- a pregnant woman can transmit the virus to her fetus through their shared blood circulation, or a nursing mother can transmit it to her baby in her milk
Other transmission methods are rare and include accidental needle injury, artificial insemination with donated semen, and organ transplants.
HIV infection is not spread by casual contact such as hugging, by touching items previously touched by a person infected with the virus, during participation in sports, or by mosquitoes.
It is not transmitted to a person who DONATES blood or organs. Those who donate organs are not in direct contact with those who receive them. Likewise, a person who donates blood is not in contact with the person receiving it. In all these procedures, sterile needles and instruments are used.
However, HIV can be transmitted to a person RECEIVING blood or organs from an infected donor. This is why blood banks and organ donor programs screen donors, blood, and tissues thoroughly.
Those at highest risk include:
- Persons engaging in unprotected sex
- Sexual partners of those who participate in high-risk activities (such as anal sex)
- Intravenous drug users who share needles
- Infants born to mothers with HIV who don't receive HIV therapy during pregnancy
- People who received blood transfusions or clotting products between 1977 and 1985 (prior to the beginning standard screening for the virus in the blood)
AIDS begins with HIV infection. People infected with HIV may have no symptoms for ten years or longer, but they can still transmit the infection to others during this symptom-free period. Meanwhile, if the infection is not detected and treated, the immune system gradually weakens, and AIDS develops.
Acute HIV infection progresses over time to asymptomatic HIV infection and then to early symptomatic HIV infection. Later, it progresses to AIDS (defined as very advanced HIV infection with T-cell count below 200).
Most individuals infected with HIV, if not treated, will develop AIDS. There is a small group of patients who develop AIDS very slowly, or never at all. These patients are called non-progressors, and many seem to have a genetic difference that prevents the virus from attaching to certain immune receptors.
The symptoms of AIDS are primarily the result of infections that do not normally develop in individuals with healthy immune systems. These are called opportunistic infections.
Patients with AIDS have had their immune system depleted by HIV and are very susceptible to such opportunistic infections. Common symptoms are fevers, sweats (particularly at night), swollen glands, chills, weakness, and weight loss.
See the signs and tests section below for a list of common opportunistic infections and major symptoms associated with them.
Note: Initial infection with HIV can produce no symptoms. Most people, however, do experience flu-like symptoms with fever, rash, sore throat, and swollen lymph nodes, usually two weeks after contracting the virus. Some people with HIV infection remain without symptoms for years between the time of exposure and development of AIDS.
The following is a list of AIDS-related infections and cancers that people with AIDS acquire as their CD4 count decreases. Previously, having AIDS was defined as having HIV infection and getting one of these additional diseases. Now it is additionally defined as a CD4 count below 200, even without an opportunistic infection. Many other illnesses and corresponding symptoms may develop in addition to those listed here.
Common with CD4 count below 350 cells/ml:
- Herpes simplex virus -- causes ulcers/vesicles in the mouth or genitals, occurring more frequently and more severely in an HIV-infected patient than before HIV infection
- Tuberculosis -- infection by the tuberculosis bacteria that predominately affects the lungs, but can affect other organs such as the bowel, lining of the heart or lungs, brain, or lining of the central nervous system
- Oral or vaginal thrush -- yeast infection of the mouth or genitals
- Herpes zoster (Shingles) -- ulcers/vesicles over a discrete patch of skin caused by the varicella zoster virus
- Non-Hodgkin's lymphoma -- cancer of the lymph glands
- Kaposi's sarcoma -- Cancer of the skin, lungs, and bowel, associated with a herpes virus (HHV-8). Can occur at any CD4 count, but more likely at lower CD4 counts, and more common in men than women
CD4 count below 200 cells/ml
- Pneumocystis carinii pneumonia, "PCP pneumonia," now called Pneumocystic jiroveci pneumonia
- Candida esophagitis -- painful yeast infection of the esophagus
- Bacillary angiomatosis -- Skin lesions caused by a bacteria called Bartonella, which is usually acquired from cat scratches
CD4 count below 100 cells/ml
- Cryptococcal meningitis -- infection of the lining of the brain by a yeast
- AIDS dementia -- worsening and slowing of mental function, caused by HIV itself
- Toxoplasmosis encephalitis -- infection of the brain by a parasite, which is frequently found in cat feces; causes discrete lesions in the brain
- Progressive multifocal leukoencephalopathy -- a viral disease of the brain caused by a virus (called the JC virus) that results in a severe decline in cognitive and motor functions
- Wasting syndrome -- extreme weight loss and loss of appetite, caused by HIV
- Cryptosporidium diarrhea -- Extreme diarrhea caused by one of several related parasites
CD4 count below 50/ml
- Mycobacterium avium -- a blood infection by a bacterium related to tuberculosis
- Cytomegalovirus infection -- a viral infection that can affect almost any organ system, especially the large bowel and the eyes
In addition to the CD4 count, HIV RNA load, and basic screening lab tests, regular vaginal Pap smears are important to monitor in HIV infection, due to the increased risk of cervical cancer in immunocompromised patients. . Anal Pap smears to detect potential cancers may also be important in both HIV infected men and women.
There is no cure for AIDS at this time. However, a variety of treatments are available that can delay the progression of disease for many years, and improve the quality of life of those who have developed symptoms.
Antiretroviral therapy suppresses the replication of the HIV virus in the body. A combination of several antiretroviral agents, termed highly active antiretroviral therapy (HAART), has been highly effective in reducing the number of HIV particles in the blood stream, as measured by a blood test called the viral load. This can help the immune system recover from the HIV infection and improve T-cell counts.
Although not a cure for HIV, and people on HAART with suppressed levels of HIV can still transmit the virus to others through sex or sharing of needles, these treatments have been enormously effective for the past ten years. There is good evidence that if the levels of HIV remain suppressed and the CD4 count remains high (above 200), life can be significantly prolonged and improved. However, HIV may become resistant to HAART in patients who do not take their medications on schedule every day. Genetic tests are now available to determine whether a particular strain is resistant to a particular drug -- these may be useful in determining the best drug combination, and adjusting the regimen if it starts to fail. These tests should be performed for any failing treatment course, and prior to starting therapy.
When HIV becomes resistant to HAART, salvage therapy is required, to try to suppress the resistant strain of HIV. Different combinations of medications are used to try to reduce viral load, and there are a variety of new drugs coming out on the market for the treatment of drug-resistant HIV.
Treatment with HAART is not without complications. HAART is a collection of different medications, each with its own side effects. Some common side effects are nausea, headache, weakness, malaise, and fat accumulation on the back and abdomen ("buffalo hump"). When used long-term, these medications increase the risk of heart attack by affecting fat breakdown, specifically through increasing lipids and glucose levels.
Any doctor prescribing HAART should carefully follow the patient for possible side effects associated with the combination of medications the patient takes. In addition, routine blood tests measuring CD4 counts and HIV viral load (a blood test that measures how much virus is in the blood) should be taken every three to four months. The goal is to get the CD4 count as close to normal as possible, and to suppress the HIV viral load to an undetectable level.
Other antiviral agents are in investigational stages and many new drugs are in development. In addition, growth factors that stimulate cell growth, such as Epogen (erthythropoetin) and G-CSF are sometimes used to treat anemia and low white blood cell counts associated with AIDS.
Medications are also used to prevent opportunistic infections (such as Pneumocystis carinii pneumonia) if the CD4 count is low enough. This keeps AIDS patients healthier for longer periods of time. Opportunistic infections are treated as they occur.
Joining support groups where members share common experiences and problems can often help the emotional stress of devastating illnesses. See AIDS - support group.
Back to TopExpectations (prognosis)
At the present time, there is no cure for AIDS. It is always fatal if no treatment is provided. In the U.S., most patients survive many years following diagnosis because of the availability of HAART. HAART has dramatically increased the time from diagnosis to death, and research continues in the areas of drug treatments and vaccine development. Unfortunately, HIV medications are not always available in the developing world, where the bulk of the epidemic is raging, due to socioeconomic reasons.
When a person is infected with HIV, the virus slowly begins to destroy that person's immune system. How fast this occurs differs in each individual. Treatment with HAART can help slow and even halt the destruction of the immune system.
Once the immune system is severely damaged, that person has AIDS, and is now susceptible to infections and cancers that most healthy adults would not get. However, antiretroviral treatment can still be very effective, even at that stage of illness.
Back to TopCalling Your Health Care Provider
Call for an appointment with your health care provider if you have any of the risk factors for HIV infection, or if symptoms of AIDS are present. By law, AIDS testing must be kept confidential. Your health care provider will review results of your testing with you.
- See the article on safe sex to learn how to reduce the chance of acquiring or spreading HIV, and other sexually transmitted diseases.
- Try not to use intravenous drugs. If IV drugs are used, do not share needles or syringes. Many communities now have needle exchange programs, where used syringes can be disposed of and new, sterile needles obtained for free. These programs can also provide referrals to addiction treatment.
- Avoid contact with another person's blood when the HIV status of the bleeding individual is unknown. Protective clothing, masks, and goggles may be appropriate when caring for people who are injured.
- Anyone who tests positive for HIV can pass the disease to others and should not donate blood, plasma, body organs, or sperm. An infected person should warn any prospective sexual partner of their HIV-positive status, should not exchange body fluids during sexual activity, and should use whatever preventive measures (such as condoms) will afford the partner the most protection.
- HIV-positive women who wish to become pregnant should seek counseling about the risk to unborn children, and medical advances which may help prevent the fetus from becoming infected. Use of certain medications can dramatically reduce the chances that the baby will become infected during pregnancy.
- Mothers who are HIV-positive should not breast feed their babies.
- Safe-sex practices, such as latex condoms, are highly effective in preventing HIV transmission. HOWEVER, there remains a risk of acquiring the infection even with the use of condoms, if the condom breaks. Abstinence is the only sure way to prevent sexual transmission of HIV.
The riskiest sexual behavior is unprotected receptive anal intercourse -- the least risky sexual behavior is receiving oral sex. Performing oral sex on a man is associated with some risk of HIV transmission, but this is less risky than unprotected vaginal intercourse. Female-to-male transmission of the virus is much less likely than male-to-female transmission. Performing oral sex on a woman who does not have her period carries low risk of transmission.
HIV-positive patients who are taking anti-retroviral medications are less likely to transmit the virus. For example, pregnant women who are on effective treatment at the time of delivery with undetectable viral loads transmit HIV to the infant
Review Date: 5/26/2006 Reviewed By: Monica Gandhi MD, MPH, Assistant Professor, Division of Infectious Diseases, UCSF, San Francisco, CA. Review provided by VeriMed Healthcare Network.
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Any sanitizer that is at least 62% alcohol works.
Also, wash with soap and water.
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Should the mats be cleaned daily?
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Wash your hands a lot. Use an alcohol based hand sanitizer (carry one in your bag so it is always at the ready). Don’t share personal items with friends (phones, make up, etc). Keep any cuts covered with a bandage until they heal. Let your doctor know if you have a sore that doesn’t seem to be healing. Encourage your friends to do the same things.
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Nonsense it is not. MRSA can thrive on gym equipment and when an open wound on the skin touches that eqipment, MRSA can grow inside the wound and cause infection. Most people who touch a piece of gym eqipment with MRSA living on it will get the MRSA bacteria on their skin and it will stay there until it’s washed off. Exposure does not cause infection every time.
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